Surescripts API
Surescripts is a network operator, not an API vendor: no developer portal exists and there is no API key to obtain. E-prescribing, EPCS, and medication history are reached through certified EHRs, pharmacy systems, or middleware like DoseSpot and DrFirst, behind contracts and certification.
Frequently asked questions
Surescripts scores F on the API Report Card. Surescripts is a network operator, not an API vendor: no developer portal exists and there is no API key to obtain. E-prescribing, EPCS, and medication history are reached through certified EHRs, pharmacy systems, or middleware like DoseSpot and DrFirst, behind contracts and certification.
Without a usable official API, teams fall back on manual exports, file drops, or one-off vendor integrations. The other option is an unofficial API layer like Supergood that automates the authenticated web app directly.
Surescripts is the dominant US health-information network, connecting roughly 2.3 million healthcare professionals and provider organizations across virtually every EHR, pharmacy, PBM, health plan, and health system.
Healthcare / Health Information Exchange. Providers e-prescribe (including controlled substances via EPCS), check patient eligibility, formulary, and real-time prescription benefit at the point of prescribing, run electronic prior authorization, reconcile medication history at intake and discharge, and exchange clinical documents (CCDs) and Direct messages for care coordination.
Very high. Surescripts routes the large majority of US e-prescriptions and connects effectively all major EHRs and pharmacies.
Patients, prescribers, pharmacies; prescriptions (NewRx, RxRenewal, RxChange, CancelRx); medication history; eligibility, formulary, and benefit responses; prior authorization requests and determinations; and clinical documents (CCDs) and Direct messages.
Founded in 2001 (from the merger of RxHub and SureScripts in 2008), Surescripts is a mature, standards-based network built on NCPDP SCRIPT, HL7, and X12 messaging.
No public developer portal or self-serve API keys; you cannot simply sign up and start sending prescriptions. Certification is rigorous, time-consuming, and expensive for new digital-health startups before production go-live. Full sourced list under Sources below.
Common alternatives include DoseSpot, DrFirst, CoverMyMeds, Weno Exchange, RXNT. Graded alternatives appear under "More from the report card" below.
Grades measure one thing: can a customer's engineering team get their own data out programmatically? We check six things (whether a real API exists, how access is gated, data coverage, auth quality, docs and developer experience, and stability) and roll them into a letter grade. Grades get re-verified, and they only move on evidence.
Yes. Supergood maintains an unofficial Surescripts API and MCP server so AI agents and internal tools can read and write Surescripts data. See the Surescripts integration docs at supergood.ai/docs/surescripts-api.